Tan YZ, Abbas YM, Wu JZ, Wu D, Keon KA, Hesketh GG, Bueler SA, Gingras AC, Robinson CV, Grinstein S and Rubinstein JL. CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7.Life Sci Alliance. 2022. PMID: 35794005.
Coelho PP, Hesketh GG, Pedersen A, Kuzmin E, Fortier AN, Bell ES, Ratcliffe CDH, Gingras AC and Park M. Endosomal LC3C-pathway selectively targets plasma membrane cargo for autophagic degradation.Nat Commun. 2022, 13(1): 3812. PMID: 35780247.
2021
Go CD, Knight JDR, Rajasekharan A, Rathod B, Hesketh GG, Abe KT, Youn JY, Samavarchi-Tehrani P, Zhang H, Zhu LY, Popiel E, Lambert JP, Coyaud É, Cheung SWT, Rajendran D, Wong CJ, Antonicka H, Pelletier L, Palazzo AF, Shoubridge EA, Raught B and Gingras AC. A proximity-dependent biotinylation map of a human cell.Nature. 2021, 595(7865): 120-124. PMID: 34079125.
Hirst J, Hesketh GG, Gingras AC and Robinson MS. Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5/SPG11/SPG15 complex.J Cell Biol. 2021. PMID: 33464297.
Kim SH, Choi JH, Wang P, Go CD, Hesketh GG, Gingras AC, Jafarnejad SM and Sonenberg N. Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation.Mol Cell. 2021, 81(2): 398-407.e4. PMID: 33340489.
2020
Hesketh GG, Papazotos F, Pawling J, Rajendran D, Knight JDR, Martinez S, Taipale M, Schramek D, Dennis JW and Gingras AC. The GATOR-Rag GTPase pathway inhibits mTORC1 activation by lysosome-derived amino acids.Science. 2020, 370(6514): 351-356. PMID: 33060361.
2018
Emmer BT, Hesketh GG, Kotnik E, Tang VT, Lascuna PJ, Xiang J, Gingras AC, Chen XW and Ginsburg D. The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9.Elife. 2018. PMID: 30251625.
Hesketh GG, Wartosch L, Davis LJ, Bright NA and Luzio JP. The Lysosome and Intracellular Signalling.Prog Mol Subcell Biol. 2018, 57: 151-180. PMID: 30097775.
Khoriaty R, Hesketh GG, Bernard A, Weyand AC, Mellacheruvu D, Zhu G, Hoenerhoff MJ, McGee B, Everett L, Adams EJ, Zhang B, Saunders TL, Nesvizhskii AI, Klionsky DJ, Shavit JA, Gingras AC and Ginsburg D. Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo.Proc Natl Acad Sci U S A. 2018, 115(33): E7748-E7757. PMID: 30065114.
Hunter MR, Hesketh GG, Benedyk TH, Gingras AC and Graham SC. Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.J Mol Biol. 2018, 430(14): 2153-2163. PMID: 29778605.
Jafarnejad SM, Chapat C, Matta-Camacho E, Gelbart IA, Hesketh GG, Arguello M, Garzia A, Kim SH, Attig J, Shapiro M, Morita M, Khoutorsky A, Alain T, Gkogkas CG, Stern-Ginossar N, Tuschl T, Gingras AC, Duchaine TF and Sonenberg N. Translational control of ERK signaling through miRNA/4EHP-directed silencing.Elife. 2018. PMID: 29412140.
2017
Hesketh GG and Dennis JW. N-acetylglucosamine: more than a silent partner in insulin resistance.Glycobiology. 2017, 27(7): 595-598. PMID: 29048482.
Chapat C, Jafarnejad SM, Matta-Camacho E, Hesketh GG, Gelbart IA, Attig J, Gkogkas CG, Alain T, Stern-Ginossar N, Fabian MR, Gingras AC, Duchaine TF and Sonenberg N. Cap-binding protein 4EHP effects translation silencing by microRNAs.Proc Natl Acad Sci U S A. 2017, 114(21): 5425-5430. PMID: 28487484.
Hesketh GG, Youn JY, Samavarchi-Tehrani P, Raught B and Gingras AC. Parallel Exploration of Interaction Space by BioID and Affinity Purification Coupled to Mass Spectrometry.Methods Mol Biol. 2017, 1550: 115-136. PMID: 28188527.
Waxse BJ, Sengupta P, Hesketh GG, Lippincott-Schwartz J and Buss F. Myosin VI facilitates connexin 43 gap junction accretion.J Cell Sci. 2017, 130(5): 827-840. PMID: 28096472.
2016
Dennis MK, Delevoye C, Acosta-Ruiz A, Hurbain I, Romao M, Hesketh GG, Goff PS, Sviderskaya EV, Bennett DC, Luzio JP, Galli T, Owen DJ, Raposo G and Marks MS. BLOC-1 and BLOC-3 regulate VAMP7 cycling to and from melanosomes via distinct tubular transport carriers.J Cell Biol. 2016, 214(3): 293-308. PMID: 27482051.
2014
Hesketh GG, Pérez-Dorado I, Jackson LP, Wartosch L, Schäfer IB, Gray SR, McCoy AJ, Zeldin OB, Garman EF, Harbour ME, Evans PR, Seaman MNJ, Luzio JP and Owen DJ. VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surface.Dev Cell. 2014, 29(5): 591-606. PMID: 24856514.
Aiba T, Farinelli F, Kostecki G, Hesketh GG, Edwards D, Biswas S, Tung L and Tomaselli GF. A mutation causing Brugada syndrome identifies a mechanism for altered autonomic and oxidant regulation of cardiac sodium currents.Circ Cardiovasc Genet. 2014, 7(3): 249-56. PMID: 24795344.
Freeman CL, Hesketh G and Seaman MN. RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation.J Cell Sci. 2014, 127(Pt 9): 2053-70. PMID: 24643499.
Smyth JW, Zhang SS, Sanchez JM, Lamouille S, Vogan JM, Hesketh GG, Hong T, Tomaselli GF and Shaw RM. A 14-3-3 mode-1 binding motif initiates gap junction internalization during acute cardiac ischemia.Traffic. 2014, 15(6): 684-99. PMID: 24612377.
2013
Aiba T, Barth AS, Hesketh GG, Hashambhoy YL, Chakir K, Tunin RS, Greenstein JL, Winslow RL, Kass DA and Tomaselli GF. Cardiac resynchronization therapy improves altered Na channel gating in canine model of dyssynchronous heart failure.Circ Arrhythm Electrophysiol. 2013, 6(3): 546-54. PMID: 23650309.
2012
Schäfer IB, Hesketh GG, Bright NA, Gray SR, Pryor PR, Evans PR, Luzio JP and Owen DJ. The binding of Varp to VAMP7 traps VAMP7 in a closed, fusogenically inactive conformation.Nat Struct Mol Biol. 2012, 19(12): 1300-9. PMID: 23104059.
2011
Gebska MA, Stevenson BK, Hemnes AR, Bivalacqua TJ, Haile A, Hesketh GG, Murray CI, Zaiman AL, Halushka MK, Krongkaew N, Strong TD, Cooke CA, El-Haddad H, Tuder RM, Berkowitz DE and Champion HC. Phosphodiesterase-5A (PDE5A) is localized to the endothelial caveolae and modulates NOS3 activity.Cardiovasc Res. 2011, 90(2): 353-63. PMID: 21421555.
2010
Hesketh GG, Shah MH, Halperin VL, Cooke CA, Akar FG, Yen TE, Kass DA, Machamer CE, Van Eyk JE and Tomaselli GF. Ultrastructure and regulation of lateralized connexin43 in the failing heart.Circ Res. 2010, 106(6): 1153-63. PMID: 20167932.
Koitabashi N, Aiba T, Hesketh GG, Rowell J, Zhang M, Takimoto E, Tomaselli GF and Kass DA. Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition.J Mol Cell Cardiol. 2010, 48(4): 713-24. PMID: 19961855.
Aiba T, Hesketh GG, Liu T, Carlisle R, Villa-Abrille MC, O'Rourke B, Akar FG and Tomaselli GF. Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes.Cardiovasc Res. 2010, 85(3): 454-63. PMID: 19797425.
2009
Hesketh GG, Van Eyk JE and Tomaselli GF. Mechanisms of gap junction traffic in health and disease.J Cardiovasc Pharmacol. 2009, 54(4): 263-72. PMID: 19701097.
Aiba T, Hesketh GG, Barth AS, Liu T, Daya S, Chakir K, Dimaano VL, Abraham TP, O'Rourke B, Akar FG, Kass DA and Tomaselli GF. Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy.Circulation. 2009, 119(9): 1220-30. PMID: 19237662.
Sekar RB, Kizana E, Cho HC, Molitoris JM, Hesketh GG, Eaton BP, Marbán E and Tung L. IK1 heterogeneity affects genesis and stability of spiral waves in cardiac myocyte monolayers.Circ Res. 2009, 104(3): 355-64. PMID: 19122180.
2007
Akar FG, Nass RD, Hahn S, Cingolani E, Shah M, Hesketh GG, DiSilvestre D, Tunin RS, Kass DA and Tomaselli GF. Dynamic changes in conduction velocity and gap junction properties during development of pacing-induced heart failure.Am J Physiol Heart Circ Physiol. 2007, 293(2): H1223-30. PMID: 17434978.
2002
Simpson JA, Labugger R, Hesketh GG, D'Arsigny C, O'Donnell D, Matsumoto N, Collier CP, Iscoe S and Van Eyk JE. Differential detection of skeletal troponin I isoforms in serum of a patient with rhabdomyolysis: markers of muscle injury?Clin Chem. 2002, 48(7): 1112-4. PMID: 12089186.